PETACH TIKVA, Israel, June 2, 2025 /PRNewswire/ — ASP Isotopes Inc. (NASDAQ: ASPI) and Isotopia Molecular Imaging Ltd. have entered right into a strategic settlement to safe the provision of Gadolinium-160 (Gd-160), a important precursor isotope for producing Terbium-161 (Tb-161), an rising medical isotope with important potential in focused radiotherapeutics.
This partnership addresses longstanding provide challenges for Gd-160, enabling Isotopia to advance Tb-161-based therapies for prostate most cancers, neuroendocrine tumors, and different malignancies.
Underneath the settlement, ASP Isotopes will leverage its proprietary Quantum Enrichment know-how to supply Isotopia with enriched Gd-160, a secure isotope important for manufacturing Tb-161.
The collaboration combines ASP Isotopes’ experience in large-scale isotope enrichment—beforehand demonstrated by its manufacturing of Ytterbium-176 (Yb-176)—with Isotopia’s confirmed capabilities in commercial-scale medical isotope manufacturing. Isotopia has persistently manufactured Lutetium-177 (Lu-177) and maintained weekly Tb-161 manufacturing for its medical trials over the previous two years.
Paul Mann, CEO of ASP Isotopes, emphasised the settlement’s significance: “By supplying Gd-160, we’re eliminating a significant bottleneck within the improvement of Tb-161 therapies. Our funding in enrichment know-how positions us to assist the radiopharmaceutical trade’s rising demand for secure isotopes. This partnership accelerates the trail to medical adoption of Tb-161, which might redefine most cancers therapy paradigms.”
Dr. Eli Shalom, CEO of Isotopia, highlighted Tb-161’s therapeutic benefits: “Tb-161’s twin mechanism of motion, together with Auger electron emissions, permits exact focusing on of micro-metastases whereas minimizing injury to wholesome tissues. This partnership ensures a dependable Gd-160 provide chain, permitting us to scale manufacturing and advance our Tb-161-labeled drug candidates towards commercialization. We produce in our website in Israel and shortly the manufacturing will begin in our second website in Indianapolis within the US.”
Tb-161’s Auger electrons induce double-strand DNA breaks in most cancers cells, providing potential benefits over Lu-177 and alpha-emitting isotopes. This precision aligns with the oncology discipline’s shift towards focused radiotherapeutics, which enhance efficacy and scale back unwanted effects. The settlement comes as international curiosity in radiopharmaceuticals surges, pushed by their capability to ship localized radiation remedy by way of tumor-seeking molecules.
About ASP Isotopes Inc.
ASP Isotopes Inc. focuses on superior isotope separation applied sciences, together with its proprietary Aerodynamic Separation Course of and Quantum Enrichment, which produce secure isotopes with out radioactive waste. The corporate’s preliminary focus is on producing and commercializing extremely enriched isotopes for the healthcare and know-how industries. The Firm has isotope enrichment amenities in Pretoria, South Africa. For extra info, please go to www.aspisotopes.com.
About Isotopia Molecular Imaging Ltd.
Isotopia is a worldwide chief in medical isotope manufacturing, with amenities in Israel, Europe, and the U.S. Its built-in platform contains cyclotrons, Lu-177 and Tb-161 manufacturing websites, and sterile manufacturing capabilities. The corporate collaborates with researchers and clinicians to develop novel radiopharmaceuticals for diagnostics and focused remedy.
This partnership positions each corporations on the forefront of the radiopharmaceutical revolution, with the potential to increase therapy choices for most cancers sufferers worldwide.
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